Brumaghim Group Publications

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(59) Murphy, J., Gaertner, A. A. E.; Owen, A. M.; Studer, S.; McMillen, C. D.; Brumaghim, J. L. “Coordination Complexes of Methimazole with Copper: Controlling Redox Reactions and Sulfur Extrusion,” Inorg. Chim. Acta 2020, 507, 119568 (DOI: 10.1016/j.ica.2020.119568).

(58) Murphy, J. M.; Powell, B. A.; Brumaghim, J. L. “Stability Constants of Bio-Relevant, Redox-Active Metals with Amino Acids: The Challenges of Weakly Binding Ligands,” Coord. Chem. Rev. 2020, 412, 213253 (DOI: 10.1016/j.ccr.2020.213253).

(57) Stadelman, B. S.; Murphy, J. M.; Owen, A. M.; Castro-Ramírez, R.; Smith, H.C.: Cohen, C. A.; Zhang, L. X.; Bayse, C. A.; McMillen, C. D.; Barba-Behrens, N.; Brumaghim, J. L. “Zinc(II) Thione and Selone Complexes: The Effect of Metal Redox Activity on Ligand Oxidation,” Inorg. Chim. Acta 2020, 502, 119379 (DOI: 10.1016/j.ica.2019.119379).

(56) Murphy, J. M.; Gaertner, A. A. E.; Williams, T.; McMillen, C. D.; Powell, B. A.; Brumaghim, J. L. “Stability Constant Determination of Sulfur and Selenium Amino Acids with Cu(II) and Fe(II),” J. Inorg. Biochem. 2019, 195, 20-30 (DOI: 10.1016/j.jinorgbio.2019.03.001).

(55) Peng, C. A.: Gaertner, A. A. E.; Henriquez, S. A.; Fang, D.; Brumaghim, J. L.; Kozubowski, L. “Fluconazole Resistance in Cryptococcus neoformans Involves Metallothionein-Independent Protection Against Fluconazole-Induced Oxidative Stress,” PLoS One 2018, 13, e0208471 (DOI: 10.1371/journal.pone.0208471).

(54) Patel, U.; Abbas, M. A.; McMillen, C. D.; Brumaghim, J. L. “Selective Cation and Anion Guest Binding in Host Selenazamacrocycles,” Dalton Trans. 2018, 47, 12066-12070 (DOI: 10.1039/C8DT02110D).

(53) Castro-Ramírez, R.; Ortiz-Pastrana, N.; Caballero, A. B.; Zimmerman, M. T.; Stadelman, B. S.; Gaertner, A. A. E.; Brumaghim, J. L.; Korrodi-Gregório, L.; Pérez-Tomás, R.; Gamez, P.; Barba-Behrens, N. “DNA Interactions of Non-Chelating Tinidazole-Based Coordination Compounds and Their Structural, Redox and Cytotoxic Properties,” Dalton Trans. 2018, 47, 7551-7560 (DOI: 10.1039/C8DT00716K).

(52) Abbas, M. A.; McMillen, C. D.; Brumaghim, J. L. “Synthesis, Characterization, and Structures of Ruthenium(II) Complexes with Multiple Solvato Ligands,” Inorg. Chim. Acta 2017, 468, 308-315 (DOI: 10.1016/j.ica.2017.07.003).

(51) Angelé-Martínez, C.; Nguyen, K. V. T.; Ameer, F. S.; Anker, J. N.; Brumaghim, J. L. “Reactive Oxygen Species Generation by Copper(II) Oxide Nanoparticles Determined by DNA Damage Assays and EPR Spectroscopy,” Nanotoxicology 2017, 11, 278-288 (DOI: 10.1080/17435390.2017.1293750).

(50) Summers, J. S.; Hickman, B; Arrington, M. E.; Stadelman, B. S.; Brumaghim, J. L.; Yost, M. R.; Schmitt, J. D.; Hornby, M.; Sprague, S. “Reaction of Oxidized CuZnSOD with Polyphenols,”Natural Sci. 2016, 8, 359-379 (DOI: 10.4236/ns.2016.88041).

(49) Stadelman, B.S; Kimani, M. M.; Bayse, C. A.; McMillen, C. D.; Brumaghim, J. L. “Synthesis, Characterization, DFT Calculations, and Electrochemical Comparison of Novel Iron(II) Complexes with Thione and Selone Ligands,”Dalton Trans. 2016, 45, 4697-4711 (DOI: 10.1039/C5DT03384E).

(48) McCoy, C. R.; Stadelman, B. S.; Brumaghim, J. L.; Liu, J.-T.; Bain, L. J. “Arsenic and Its Methylated Metabolites Inhibit the Differentiation of Neural Plate Border Specifier Cells,”Chem. Res. Toxicol. 2015, 28, 1409-1421 (DOI: 10.1021/acs.chemrestox.5b00036).

(47) Kimani, M. M.; Watts, D.; Graham, L. A.; Rabinovich, D.; Yap, G. P. A.; Brumaghim, J. L. “Dinuclear Copper(I) Complexes with N-heterocyclic Thione and Selone Ligands: Synthesis, Characterization, and Electrochemical Studies,”Dalton Trans. 2015, 44, 16313-16324 (DOI: 10.1039/C5DT02232K).

(46) Zimmerman, M. T.; Bayse, C. A.; Ramoutar, R. R.; Brumaghim, J. L. “Sulfur and Selenium Antioxidants: Challenging Radical Scavenging Mechanisms and Developing Structure-Activity Relationships Based on Metal Binding,”J. Inorg. Biochem. 2015, 145, 30-40 (invited review; DOI: 10.1016/j.jinorgbio.2014.12.020).

(45) Betanzos-Lara, S.; Chmel, N. P.; Zimmerman, M. T.; Barrón-Sosa, L. R.; Garino, C; Salassa, L; Rodger, A.; Brumaghim, J. L.; Gracia-Mora, I.; Barba-Behrens, N. “Redox-Active and DNA-Binding Coordination Complexes of Clotrimazole,” Dalton Trans. 2015, 44, 3673-3675 (invited paper for a special issue on metal complex binding to nucleic acids; DOI: 10.1039/C4DT02883J)).

(44) Angelé-Martínez, C.; Goodman, C.; Brumaghim, J. L. “Metal-Mediated DNA Damage and Cell Death: Mechanisms, Detection Methods, and Cellular Consequences,”Metallomics 2014, 6, 1358-1381 (DOI: 10.1039/c4mt00057a).

(43) Gross, C. L.; Brumaghim, J. L.; Jefferis, J. M. Dickinson, P. W.; Girolami, G. S.; Gribble, C. W.; Tilley, T. D. “Mono(η5-Pentamethylcyclopentadienyl) Complexes of Osmium,”Inorg. Synth. 2014, 36, 74-78 (DOI: 10.1002/9781118744994.ch15).

(42) Kimani, M. M.; Bayse, C. A.; Stadelman, B. S.; Brumaghim, J. L. “Oxidation of Biologically Relevant Chalcogenones and Their Cu(I) Complexes: Insights into Selenium and Sulfur Antioxidant Activity,”Inorg. Chem. 2013, 52, 11685-11687 (DOI: 10.1021/ic401366c).

(41) Stadelman, B. S.; Brumaghim, J. L. “Thione- and Selone-Containing Compounds, Their Late First Row Transition Metal Coordination Chemistry, and Their Biological Potential,” In Biochalcogen Chemistry: The Biological Chemistry of Sulfur, Selenium, and Tellurium; Bayse, C. A.; Brumaghim, J. L. eds.; ACS Symposium Series; American Chemical Society: Washington, DC, 2013, pp. 33-70 (DOI:

(40) Underwood, C. C.; Stadelman, B. S.; Sleeper, M. L.; Brumaghim, J. L. “Synthesis and Electrochemical Characterization of [Ru(NCCH3)6]2+, Tris(acetonitrile) Tris(pyrazolyl)borate, and Tris(acetonitrile) Tris(pyrazolyl)methane Ruthenium(II) Complexes,”Inorg. Chim. Acta 2013, 405, 470-476 (DOI: 0.1016/j.ica.2013.02.027).

(39) García, C. R.; Angelé-Martínez, C.; Wilkes, J. A.; Wang, H. C.; Battin E. E.; Brumaghim, J. L. “Prevention of Iron- and Copper-Mediated DNA Damage by Catecholamine and Amino Acid Neurotransmitters, L-DOPA, and Curcumin: Metal Binding as a General Antioxidant Mechanism,”Dalton Trans. 2012, 41, 6458-6467 (DOI: 10.1039/c2dt30060e).

(38) Kimani, M. M.; Wang, H. C.; Brumaghim, J. L. “Investigating the Coordination, Electrochemistry, and Cu(II) Reduction Kinetics of Biologically Relevant Selone and Thione Compounds,”Dalton Trans. 2012, 41, 5248-5259 (DOI: 10.1039/C2DT11731B).

(37) Wang, H. C.; Brumaghim, J. L. “Polyphenol Compounds as Antioxidants for Disease Prevention: Reactive Oxygen Species Scavenging, Enzyme Regulation, and Metal Chelation Mechanisms in E. coli and Human Cells,” In Oxidative Stress: Diagnostics, Prevention, and Therapy; Andreescu, S.; Hepel, M., eds.; ACS Symposium Series; American Chemical Society: Washington, DC, 2011, pp. 99-175 (DOI: 10.1021/bk-2011-1083.ch005).

(36) Wang, H. C; Riahi, M.; Pothen, J.; Bayse, C. A.; Riggs-Gelasco, P.; Brumaghim, J. L. “Interactions of Cu(I) with Selenium-Containing Amino Acids Determined by NMR, XAS, and DFT Studies,”Inorg. Chem. 2011, 50, 10893-10900 (DOI: 10.1021/ic201440j).

(35) Quarles, C. D.; Marcus, R. K.; Brumaghim, J. L. “Metal Retention in Human Transferrin: Consequences of Solvent Composition in Analytical Sample Preparation Methods,”Metallomics 2011, 3, 1027-1034 (DOI: 10.1039/c1mt00094b).

(34) Verdan, A. M.; García, C. R.; Wang, H. C.; Henry, W. P.; Brumaghim, J. L. “Iron Binding of 3-Hydroxychromone, 5-Hydroxychromone, and Sulfonated Morin: Implications for the Antioxidant Activity of Flavonols with Competing Metal Binding Sites,”J. Inorg. Biochem. 2011, 105, 1314-1322 (DOI: 10.1016/j.jinorgbio.2011.07.006).

(33) Quarles, C. D.; Marcus, R. K.; Brumaghim, J. L. “Competitive Binding of Fe,3+, Cr3+, and Ni2+ to Transferrin,”J. Biol. Inorg. Chem. 2011, 16, 913-921 (DOI: 10.1007/s00775-011-0792-9).

(32) Kimani, M. M.; VanDerveer, D.; Brumaghim, J. L. “The Diselanylbis(1,3-dimethyl-1H-imidazol-3-ium) Dication Stabilized by the Polymeric catena-Pentachloridotricuprate(I) Anion,”Acta Crystallogr. 2011, C67, m208-m210 (DOI: 10.1107/S0108270111018117).

(31) Grimland, J.; Wu, C.; Ramoutar, R. R.; Brumaghim, J. L.; McNeill, J. “Highly Efficient Singlet Oxygen Generation by Polymer Nanoparticles,”Nanoscale 2011, 3, 1451-1455 (DOI: 10.1002/chem.201404378).

(30) Kimani, M. M.; Bayse, C. A.; Brumaghim, J. L. “Synthesis, Characterization, and DFT Studies of Thione and Selone Cu(I) Complexes with Variable Coordination Geometries,”Dalton Trans. 2011, 40, 3711-3723 (DOI: 10.1039/C1DT10104H)

(29) Perron, N. P.; García, C. R.; Pinzón, J. R.; Chaur, M. N.; Brumaghim, J. L. “Antioxidant and Prooxidant Effects of Polyphenol Compounds on Copper-Mediated DNA Damage,”J. Inorg. Biochem. 2011, 105, 745-753 (DOI: 10.1016/j.jinorgbio.2011.02.009).

(28) Battin, E. E.; Zimmerman, M. T.; Ramoutar, R. R.; Quarles, C. E.; Brumaghim, J. L. “Preventing Metal-Mediated Oxidative DNA Damage with Selenium Compounds,”Metallomics 2011, 3, 503-512 (DOI: 10.1039/c0mt00063a).

(27) Quarles, C. D.; Brumaghim, J. L; Marcus, R. K. “Instrumental Comparison of the Determination of Cr3+ Uptake by Human Transferrin,”Metallomics 2010, 2, 792-799 (DOI: 10.1039/C0MT00032A; cover article).

(26) Perron, N. R.; Wang, H. C.; DeGuire, S. N.; Jenkins, M.; Lawson, M.; Brumaghim, J. L. “Kinetics of Iron Oxidation upon Polyphenol Binding,”Dalton Trans. 2010, 39, 9982-9987 (DOI: 10.1039/c0dt00752h).

(25) Kimani, M. M.; Brumaghim, J. L.; VanDerveer, D. “Probing the Antioxidant Action of Selenium and Sulfur Using Cu(I)-Chalcogenone Tris(pyrazolyl)methane and -borate Complexes,”Inorg. Chem. 2010, 49, 9200-9211 (DOI: 10.1021/ic100668b).

(24) Ramoutar, R. R.; Brumaghim, J. L. “A Review of the Antioxidant and Anticancer Properties and Mechanisms of Inorganic Selenium, Oxo-Sulfur, and Oxo-Selenium Compounds,”Cell Biochem. Biophys. 2010, 58, 1-23 (DOI: 10.1007/s12013-010-9088-x).

(23) Quarles, C. D., Jr.; Brumaghim, J. L.; Marcus, R. K. “Simultaneous Multiple Element Detection by Particle Beam/Hollow Cathode-Optical Emission Spectroscopy as a Tool for Metallomic Studies: Determinations of Metal Binding with Apo-Transferrin,”Metallomics 2010, 2, 154-161 (DOI: 10.1039/B916073F).

(22) Battin, E.B.; Brumaghim, J.L. “Antioxidant Activity of Sulfur and Selenium: A Review of Reactive Oxygen Species Scavenging, Glutathione Peroxidase, and Metal Binding Antioxidant Mechanisms,” Cell Biochem. Biophys. 2009, 55, 1-23 (DOI: 10.1007/s12013-009-9054-7; invited review).

(21) Battin, E.B.; Lawhon, A.; Hamilton, D.H.; Brumaghim, J.L. “Using Proteins in a Bioinorganic Laboratory Experiment: Iron Loading and Removal from Transferrin,” J. Chem. Ed. 2009, 86, 969-972 (DOI: 10.1021/ed086p969).

(20) Perron, N.R.; Brumaghim, J.L. “A Review of the Iron-Binding Mechanism for Polyphenol Antioxidant Activity,” Cell Biochem. Biophys. 2009, 53, 75-100 (DOI: 10.1007/s12013-009-9043-x; invited review).

(19) Battin, E.E.; Brumaghim, J.L. “Metal Specificity in DNA Damage Prevention by Sulfur Antioxidants,” J. Inorg. Biochem. 2008, 102, 2036-2042 (DOI: 10.1016/j.jinorgbio.2008.06.010; winner of Best Paper by a Young Investigator 2008). pdf

(18) Perron, N.R; Hodges, J.N.; Jenkins, M.; Brumaghim, J.L. “Predicting How Polyphenol Antioxidants Prevent DNA Damage by Binding to Iron,”Inorg. Chem. 2008, 47, 6153-6161 (DOI: 10.1021/ic7022727).

(17) Ramoutar, R.R.; Brumaghim, J.L. “Investigating the Antioxidant Properties of Oxo-Sulfur Compounds on Metal-Mediated DNA Damage,” Main Group Chem. 2007, 101, 1028-1035 (DOI: 10.1080/10241220802012387).

(16) Ramoutar, R.R.; Brumaghim, J.L. “Effects of Inorganic Selenium Compounds on Oxidative DNA Damage,” J. Inorg. Biochem. 2007, 101, 1028-1035 (DOI: 10.1016/j.jinorgbio.2007.03.016).

(15) Gross, C.L.; Brumaghim, J.L.; Girolami, G.S. "Synthesis and Reactivity of the Osmium(III) Pentamethylcyclopentadienyl Complex (C5Me5)2Os2Br4. X-ray Crystal Structures of (C5Me5)2Os2Br4, (C5Me5)2Os2(μ-O)Br4, and (C5Me5)2Os2(μ-NPh)2Br2," Organometallics, 2007, 26, 2258-2265 (DOI: 10.1021/om060983u).

(14) Sathyamurthy, R.; Brumaghim, J.L.; VanDerveer, D.G. "Structure of 'bis(methoxymagnesium)diselenide': A Reagent for the Introduction of Selenium into Organic Molecules," J. Chem. Cryst. 2007, 37, 109-117 (DOI: 10.1007/s10870-006-9156-7).

(13) Brumaghim, J.L.; Gross, C.L.; Girolami, G.S. "Synthesis, Characterization, and Crystal Structures of the Osmium Triflate Complexes Cp*Os(P-P)(OTf) and [Cp*Os(P-P)(OH2)][OTf]," J. Organomet. Chem. 2006, 691, 3874-3880 (DOI: 10.1016/j.jorganchem.2006.05.040).

(12) Battin, E.E.; Perron, N.R.; Brumaghim, J.L. “The Central Role of Metal Ion Coordination in Selenium Antioxidant Activity,” Inorg. Chem. 2006, 45, 499-501 (DOI: 10.1021/ic051594f).

(11) Brumaghim, J.L.; Michels, M.; Pagliero, D; Raymond, K.N. “Encapsulation and Stabilization of Reactive Aromatic Diazonium Ions and the Tropylium Ion within a Supramolecular Host,” Eur. J. Org. Chem. 2004, 24 5115-5118 (DOI: 10.1002/ejoc.200400533).

(10) Brumaghim, J.L.; Michels, M.; Raymond, K.N. “Hydrophobic Chemistry in Aqueous Solution: Stabilization and Stereoselective Encapsulation of Phosphonium Guests in a Supramolecular Host," Eur. J. Org. Chem. 2004, 22, 4552-4559 (DOI: 10.1002/ejoc.200400428).

(9) Fiedler, D.; Pagliero, D; Brumaghim, J.L.; Bergman, R.G.; Raymond, K.N. “Encapsulation of Cationic Ruthenium Complexes into a Chiral Self-Assembled Cage,” Inorg. Chem. 2004, 43, 846-848 (DOI: 10.1021/ic035105s).

(8) Brumaghim, J.L.; Li, Y.; Henle, E.; Linn, S. “Effects of Hydrogen Peroxide upon Nicotinamide Nucleotide Metabolism in Escherichia coli: Changes in Enzyme Levels and Nicotinamide Nucleotide Pools and Studies of the Oxidation of NAD(P)H by Fe(III),” J. Biol. Chem. 2003, 278, 42495-42504 (DOI: 10.1074/jbc.M306251200).

(7) Brumaghim, J.L.; Raymond, K.N. “What Should Be Impossible: Resolution of the Mononuclear Gallium Coordination Complex, Tris(benzohydroxamato)gallium(III).” J. Am. Chem. Soc. 2003, 125, 12066-12067 (DOI: 10.1021/ja0360283).

(6) Ziegler, M.; Brumaghim, J.L.; Raymond, K.N. "Stabilization of a Reactive Cationic Species by Supramolecular Encapsulation," Angew. Chem. Int. Ed. 2000, 39, 4119-4121 (DOI: 10.1002/1521-3757(20001117)112:22<4285::AID-ANGE4285>3.0.CO;2-D).

(5) Brumaghim, J.L.; Girolami, G.S. "An Unusual Norbornadiene Coupling Product: Synthesis, Characterization, and Structure of the Ruthenocene (C5Me5)Ru(η5-C5H4C9H11)," J. Organomet. Chem. 1999, 586, 258-262 (DOI: 10.1016/S0022-328X(99)00256-9).

(4) Mui, H.D.; Brumaghim, J.L.; Gross, C.L.; Girolami, G.S. "Synthesis of Hydride and Alkyl Compounds Containing the Cp*Os(η3-allyl) Fragment. Crystal Structures of Cp*Os(η3-C8H13)Br2 and [Cp*Os(η3-C4H7)Me(H2O)][BF4]," Organometallics 1999, 18, 3264-3272 (DOI: 10.1021/om990150m).

(3) Brumaghim, J.L.; Girolami, G.S. "Synthesis and Reactivity of the Osmium Methylidene Complex [(C5Me5)Os(:CH2)(dppm)][OTf]," Chem. Commun. 1999, 953-954 ( DOI: 10.1039/A901644I).

(2) Brumaghim, J.L.; Priepot, J.G.; Girolami, G.S. "Synthesis of Hydride and Alkyl Compounds Containing the Cp*Os(NO) Fragment. Crystal Structure of [Cp*Os(μ-NO)]2," Organometallics 1999, 18, 2139-2144 (DOI: 10.1021/om980657h).

(1) Brumaghim, J.L.; Girolami, G.S. "Ring-Opening Metathesis Polymerization of Norbornene by Cp*2Os2Br4 and Related Compounds," Organometallics 1999, 18, 1923-1929 (DOI: 10.1021/om980434r).