Prof. Julia Brumaghim
Contact Information Academic vitae Dr. Brumaghim first became interested in research chemistry as an undergraduate after conducting undergraduate research in the laboratories of Professors George Whitesides and Andrew Barron at Harvard, and Richard Eisenberg at the University of Rochester, primarily in synthetic inorganic chemistry. During graduate school at the University of Illinois, she worked with Professor Greg Girolami to synthesize and characterize air- and moisture-sensitive osmium complexes containing the pentamethylcyclopentadienyl ligand. Seeking to focus on biological applications of inorganic chemistry, Dr. Brumaghim then began an NIH postdocotoral fellowship with Professor Ken Raymond in the Chemistry Department at the University of California at Berkeley. Having assiduously avoided water and oxygen during most of her graduate tenure, she now performed much of her work in water. Using Ga(III) to mimic Fe(III), Dr. Brumaghim synthesized and resolved chiral Ga(III) hydroxamate complexes. Drawing on her graduate training in organometallic catalysis, she also studied the incorporation of chiral phosphonium cations and ruthenium catalysts into the Raymond supramolecular assemblies. To gain more experience working with DNA, Dr. Brumaghim accepted a second postdoctoral research position with Professor Stuart Linn in the Molecular and Cellular Biology department at Berkeley. There she studied the effects of iron coordination on oxidative DNA damage and determined sites for iron localization and reduction rates for the biological reductants NAD(P)H.
As a chemistry professor at Clemson University, Dr. Brumaghim's work focuses on the biological applications of inorganic chemistry,
using a wide range of techniques to determine mechanisms of antioxidant activity and prevention of metal-mediated DNA damage. |